Isolation and Hypoglycemic Activity of Ephedrans A, B, C, D and E, Glycans of Ephedra distachya Herbs1

Chohachi Konno; Takakazu Mizuno; Hiroshi Hikino

doi:10.1055/s-2007-969437

Planta Medica, Table of Contents

Planta Med 1985; 51(2): 162-163
DOI: 10.1055/s-2007-969437

Reports

Isolation and Hypoglycemic Activity of Ephedrans A, B, C, D and E, Glycans of Ephedra distachya Herbs¹

Chohachi Konno, Takakazu Mizuno, Hiroshi Hikino

Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

1 Antidiabetes drugs, Part 6 and the constituents of Ephedra, Part 20. Also Part 83 in the validity of the Oriental medicines

Abstract

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Abstract

Administration of an aqueous methanol/water extract of the Oriental crude drug “maō” (Ephedra), Ephedra distachya herbs, caused transient hyperglycemia followed by long lasting hypoglycemia in mice. Activity-guided fractionation of the extract led to isolation of five glycans, ephedrans A, B, C, D and E, which exhibited significant hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.

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